I investigated the relation of resilience to menopausal and depressive symptoms in middle-aged women with or without depression. Questionnaires for 300 healthy women were given through the Internet while 92 patients had them handed out at a clinic. The patient group has significantly higher physical menopausal and depressive symptoms than the healthy group. The healthy group has significantly higher resilience than the patient group. Physical menopausal symptoms gave positive influence on depressive symptoms in the 2 groups.. On the other hand the age and resilience gave negative influence on depressive symptoms. Therefore resilience may indirectly give a negative influence to physical menopausal symptoms.